buy Zopiclone Zaleplon Zolpidem This study comprised a phase III, single-center, randomized, double-blind, double-dummy, parallel-group, non-inferiority trial. Patients were randomized to receive zopiclone 7.5 mg or eszopiclone 3 mg, both orally, for four weeks. In total, 199 patients were evaluated during two visits and then followed for at least six weeks. The primary endpoint was the Insomnia Severity Index after four weeks of treatment. Secondary endpoints were obtained through polysomnography data, including total sleep time, sleep latency and sleep efficiency. The frequency of adverse events was also analyzed.
The primary efficacy analysis demonstrated the non-inferiority of eszopiclone over zopiclone. Analysis of objective parameters assessed by polysomnography showed that eszopiclone increased total sleep time and also improved sleep efficiency. The safety profile of both study treatments was similar and the most common events reported in both groups were dysgeusia, headache, dizziness, irritability and nausea.
buy Zopiclone Zaleplon Zolpidem Chronic insomnia affects 15% of the population 1. Although the health consequences can be severe, few patients with this disorder are diagnosed and treated appropriately. In addition to negative impacts on a wide range of daytime functions, affecting social, emotional and physical domains, chronic insomnia affects cognitive and physical functioning 2. Indeed, compared with people who do not suffer from insomnia, those who present this affliction are more prone to accidents and have higher rates of work absenteeism, decreased work performance, decreased quality of life and increased use of health care resources 3,4. Successful treatment of insomnia depends on a correct diagnosis, appropriate behavioral measures, and particularly, the use of safe and effective drugs.
Several risk factors associated with higher chronic insomnia prevalence include advanced age, female sex and the presence of comorbidities and psychiatric disorders. In fact, approximately 40% of adults with insomnia also have a diagnosable psychiatric disorder,
buy Zopiclone Zaleplon Zolpidem The diagnosis is essentially clinical and based primarily on a detailed medical history, with some additional tools for corroboration, such as sleep diaries, actigraphy and polysomnography. The impact of insomnia on the quality of life of affected individuals has been widely studied. Drugs used to treat insomnia include hypnotics or sleep inducers as well as antidepressants with a sedative effect 8. Among hypnotics, sleep inducers with selective action on GABA-A receptors, such as zolpidem, zopiclone, eszopiclone and zaleplon
Based on the Insomnia Severity Index at the end of four weeks of treatment, eszopiclone demonstrated efficacy comparable to that of zopiclone in the treatment of insomnia, increasing total sleep time as well as sleep efficiency according to polysomnography.